From pfpc@istar.ca Mon Oct 9 09:21:26 2000 Date: Sat, 7 Oct 2000 18:12:12 -0800 From: PFPC To: Jane Jones Subject: OPEN LETTER TO FIONA GODLEE/BMJ It's time to cross the great river. We're all in the same boat. ------------------- OPEN LETTER TO FIONA GODLEE and all WAME members October 6, 2000 TO: FIONA GODLEE Editor, Clinical Evidence; President, World Association of Medical Editors (WAME) Dear Fiona, Not long ago the BMJ rejected a review detailing the action of aluminum fluoride compounds on G proteins by a well-respected Professor of Physiology at one of Europe's oldest Universities with the explanation that it would be of "no interest to the readers of the BMJ." This despite the fact that a) 60% of all currently available medications are thought to act via G proteins b) effects of fluoride on bone are now identified to be due to the formation of such compounds and G protein activation (1) c) it is firmly established that thyroid growth, hormone synthesis, etc. is regulated by G proteins. Another well-known European Journal had earlier rejected a submission with the blunt explanation that a manufacturer of sodium fluoride tablets had threatened to withdraw all advertising monies should further articles critical of fluoride be published. A Letter to the Editor of the NEJM criticizing a particularly careless editorial and alerting to the fluoride-iodine antagonism was rejected by same editor for "the letter did not directly concern the editorial or the original article to which the editorial was directed".(???) We are sad to report that these are not isolated cases. In today's issue of the BMJ (Oct.6) there are the results of the York Review on fluoridation, a review proclaimed to be the "final word" on fluoridation. You might not be aware of this, but the NHS Centre for Reviews and Dissemination at York purposely re-wrote the protocol after a submission by our group Parents of Fluoride Poisoned Children (PFPC), detailing the effects of fluoride on thyroid hormone activities and the already high intake of fluorides in the UK due to high tea consumption (2). The York Review was also informed that ALL symptoms described in the literature on the adverse effects of fluoride on human health are IDENTICAL to those ascribed to iodine deficiency (3), not exactly rocket science when one considers the fact that fluoride - the "universal" G protein activator - thus mimicks the action of thyrotropin (TSH), deemed the "natural" G protein activator in thyroid physiology (4).This also includes the condition known as "dental fluorosis", for it is well established that iodine deficiency produces enamel hypoplasia which is identical to the condition caused by excess fluoride intake. Meanwhile, the field of dentistry claims that the biochemical events leading to dental fluorosis are still "unknown"(5,6,7), and that the condition is a "cosmetic effect", and therefore of "aesthetic concern" only. Would you agree that a dental condition caused by thyroid dysfunction at the stage of enamel formation is to be seen as a matter of "aesthetic concern" only? A recent three-year study conducted in Sosnivka, Ukraine investigated the health of children afflicted with dental fluorosis and compared results to children without such enamel defects. It was found that children with dental fluorosis had more gastrointestinal diseases (37%), respiratory diseases (29.5%), bone and muscle diseases (13.8), mental disorders (11.3), skin diseases (9.4%), and 8.2% suffered from diseases of the nervous system and sensory dysfunction. As children grew older, there was also in increase in urino-genital diseases. Boys suffered more from mental, bone-muscle, and birth anomalies. The girls had more sight problems and vaginal veneral disease. In all tested groups boys were shorther than the control. In addition children with dental fluorosis had much higher caries occurrence (8). This is not news as countless papers published in the last two decades have shown that the enamel defects seen in dental fluorosis predispose to caries. (9) A few months ago communication between PFPC head Andreas Schuld and Dr. David Coggon was cc'd to and all WAME members, and receipt acknowledged. The exchange concerned a study conducted by Hillier, Coggon, et al. which was published in the Lancet (10). You are therefore presumed to be in knowledge of the ignorance displayed by Dr. Coggon not only about effects of fluoride on bone, but also utter ignorance about the involvement of thyroid hormones in the investigated disease. It is not understandable how the BMJ could have possibly allowed another study on fluoridation and hip fractures - just as erroneous - to be published as is the case in the current issue of the BMJ, "magically co-ordinated" to co-incide with the findings of the York Review. The PFPC has decided to take action against any further dis-information regarding this issue and has begun to place reference sets currently being prepared for further legal action on its website at: http://www.bruha.com/fluoride/html/references.html. The evidence presented will satisfy ALL criteria for causation as established by Sir Bradford-Hill, documenting how fluorides cause iodine deficiency, and that the perceived "benefits" of fluoridation are clearly the results of induced thyroid dysfunction. By the time the sets are completed there will be 40 000 related papers accessible, exposing the most disturbing scientific fraud which has ever been perpetrated upon an unsuspecting public, and this for over 50 years. This information will be duplicated on numerous servers around the world. We have calculated that at least one child is dying every minute as a result of fluoride-induced iodine deficiency disorders (IDD), declared by the WHO to be the world's foremost cause of preventable mental retardation, and a major public health problem in 130 countries, affecting a total of 740 million people, including one-third of the population of China - where fluoride contamination has been openly acknowledged by deputy governor Zhang Wei as the cause of Kaschin-Beck disease, thyroid cancer, as well as iodine deficiency. Entire villages are being re-located at monumental expense. (11) It is estimated that 2 million child lives are lost each year due to IDD. The major global IDD areas are identical to endemic fluorosis areas, a finding first made more than 80 years ago and which led to the discovery of the "fluoride-iodine antagonism" and the successful application of fluorides in the treatment of thousands of patients suffering from hyperthyroidism caused by excess iodine ingestion. Treatment involved sodium fluoride ointments, tablets, injections, baths containing hydrogen fluoride, as well as numerous inorganic fluoride compounds, even at doses far less than what has been estimated to be the total current intake.(12) In the year 2000, we have "natural" fluoride areas magically popping up all over the world - in areas formerly deemed "fluoride-deficient" - due to industrial contamination from petrochemical land treatment, phosphate fertilizer production, steel manufacturing, pesticide applications, coal-burning power plants, from buried fluoride rocket fuel wastes , nuclear power reactors, uranium enrichment processes, UF6 (depleted uranium) contamination, etc.etc. This simply cannot continue. Medical practitioners everywhere depend on accurate information in medical journals, untainted by economic or political motives. We ask that a press release be issued worldwide by the BMJ within 10 days of the date of this communication, stating that the results of the York review cannot be considered accurate, as vital information was not considered and purposely excluded. To start: 1) DELAYED ERUPTION (50 papers) http://www.bruha.com/fluoride/html/delayed.html 2) ALTITUDE http://www.bruha.com/fluoride/html/altitude.html 3) FLUOROSIS & BLACKS http://www.bruha.com/fluoride/html/fluorosis_blacks.html Should these links prove not accessible, we will direct you to a mirror site. We also ask that by December 24th, 2000 a full statement is issued by the BMJ, providing accurate and detailed information for the medical community AND general public about: a) Effects of all fluoride compounds on thyroid hormones b) Activity of fluoride compounds as universal G protein activators (10 microM - 10mM) c) Truthful assessment of the condition known as "dental fluorosis" Thank you. Sincerely, Graham Bottomley, Trent Harris, Andreas Schuld, Wendy Small, Bob Johannsen Executice Committee Parents of Fluoride Poisoned Children (PFPC) Vancouver, BC, Canada 1) Susa M - "Heterotrimeric G proteins as fluoride targets in bone (Review)" Int J Mol Med 3(2):115-126 (1999) http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=9917518&form=6&db=m&Dopt =b 2) COMMUNICATION WITH THE UK REVIEW http://www.bruha.com/fluoride/html/uk_review.html 3) COMPARISON TABLE:SYMPTOMS/ASSOCIATIONS - FLUORIDE POISONING/HYPOTHYROIDISM -THYROID DYSFUNCTION http://www.bruha.com/fluoride/html/symptoms_hypo_f.html 4) Laugwitz KL, Allgeier A, Offermanns S, Spicher K, Van Sande J, Dumont JE, Schultz G - "The human thyrotropin receptor: a heptahelical receptor capable of stimulating members of all four G protein families" Proc Natl Acad Sci U S A 93(1):116-20 (1996) http://www.ncbi.nlm.nih.gov/htbin-post/Entrez/query?uid=8552586&form=6&db=m&Dopt =b 5) Gerlach RF, de Souza AP, Cury JA, Line SR - "Fluoride effect on the activity of enamel matrix proteinases in vitro" Eur J Oral Sci 108(1):48-53 (2000) 6) Limeback H - "Enamel formation and the effects of fluoride" Community Dent Oral Epidemiol 22(3):144-7 (1994) 7) Wright JT, Chen SC, Hall KI, Yamauchi M, Bawden JW - "Protein characterization of fluorosed human enamel." Dent Res 75(12):1936-41 (1996) 8) ECOPRAVA Liev - Sosnivka FINAL REPORT, USAID SCIENTIFIC ASSESSMENT GRANT available from pfpc@istar.ca 9) FLUORIDE:EFFECTIVE? http://www.bruha.com/fluoride/html/effective_.html 10) Hillier S, Cooper C, Kellingray S, Russell G, Hughes H, Coggon D - "Fluoride in drinking water and risk of hip fracture in the UK: a case-control study" Lancet 355(9200):265-9 (2000) 11) China Daily , August 8, 1999 available from pfpc@istar.ca 12) FLUORIDE & THYROID http://www.bruha.com/fluoride/html/f___thyroid.html